Retrospective Case-Control Studies in Epidemiology
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Retrospective Epidemiological Studies
Case-Control Studies
Retrospective = effect → cause. Case-control studies identify two existing groups that differ in outcome and compare them based on a supposed causal attribute.
- They work by comparing subjects who have the condition/disease (the cases) with patients who do not have the condition/disease but are otherwise similar (the controls).
- Advantages: relatively inexpensive; can be carried out by small teams or individual researchers; shorter in duration.
- Disadvantage: difficulty obtaining reliable information about an individual’s exposure status over time.
- Example of a successful study: demonstration of the link between tobacco smoking and lung cancer.
Characteristics
- Outcome has already occurred;