NSAID Classification and Therapeutic Uses Explained
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Classification and Therapeutic Uses of NSAIDs
Classification of NSAIDs
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are classified based on their chemical structure or COX (cyclooxygenase) enzyme selectivity.
I. Classification by COX Selectivity
1. Non-selective COX Inhibitors
These inhibit both COX-1 and COX-2 enzymes:
- Aspirin (acetylsalicylic acid)
- Ibuprofen
- Naproxen
- Indomethacin
- Ketorolac
- Diclofenac
- Piroxicam
2. Preferential COX-2 Inhibitors
These selectively inhibit COX-2 more than COX-1, but not exclusively:
- Meloxicam
- Nabumetone
- Etodolac
3. Selective COX-2 Inhibitors (Coxibs)
These minimally affect COX-1, resulting in lower GI side effects:
- Celecoxib
- Etoricoxib
- Parecoxib
- Valdecoxib (withdrawn in some countries due to cardiovascular risk)
- Rofecoxib (withdrawn