Purine Nucleotide Degradation and Uric Acid Synthesis
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Degradation of Purine Nucleotides + 50. Synthesis of Uric Acid and Its Secretion. Hyperuricaemia (Gout) - p.298
Digestion of dietary NA (dietary nucleotides):
- Small intestine: Pancreatic enzymes hydrolyze the NAs to nucleotides
- Inside mucosal cells: Degradation of purine nucleotides to nucleosides, free bases, and uric acid as end product
Degradation of de novo nucleotides:
- In liver
- Free bases are sent out from the liver and sent to peripheral tissues for salvage
Degradation of Dietary Nucleic Acids in the Small Intestine:
a) Ribonucleases and deoxyribonucleases (secreted by pancreas) hydrolyze dietary RNA and DNA to oligonucleotides
b) Pancreatic Phosphodiesterases produce a mixture of mononucleotides
c) Intestinal mucosal cells: Nucleotidases remove... Continue reading "Purine Nucleotide Degradation and Uric Acid Synthesis" »