Understanding DNA Replication, Transcription, and Genetic Code
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The Central Dogma of Molecular Biology
Replication - General Characteristics:
- DNA replication is semiconservative: each strand in the DNA double helix acts as a template for the synthesis of a new, complementary strand. The new two daughter molecules of DNA have a new strand and an old one.
- DNA polymerase III: is the enzyme that adds nucleotides to the growing DNA chain, incorporating only those that are complementary to the template. DNA polymerase III has the following characteristics:
- It can only read a template in 3’-----5’ direction so the new strand grows in 5’----3’ direction.
- It needs a pre-existing strand of nucleotides called a primer which provides a 3’-OH end to bind new nucleotides.
- It is able to repair the mistakes by removing