Metabolic Pathways and Liposome Drug Delivery
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Metabolic and Biochemical Processes
BMI Calculation: BMI = Kg/M2. Interpretation: <25 = Normal, 25-30 = Overweight, >30 = Obese. Ethanolamine (Ethan-NH3), Choline = N(CH3)3
Leptin and Adipose Tissue
Leptin is released from adipose tissue when mass is high. It travels through the blood to the arcuate nucleus, binds to neuronal cells, and activates the JAK-STAT pathway. This increases gene expression of POMC, which produces alpha-MSH (a neurotransmitter). Alpha-MSH reaches neurons connected to adipose tissue, releasing norepinephrine. Norepinephrine binds to beta-adrenergic receptors on adipose tissue, promoting an increase (via the G-protein coupled receptor pathway and activation of PKA). This leads to upregulation of UCP1 expression and... Continue reading "Metabolic Pathways and Liposome Drug Delivery" »