Clinical Management and Pharmacotherapy for Erectile Dysfunction and PE
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Premature Ejaculation (PE) Management
Dapoxetine (Priligy)
Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that modulates the ejaculatory reflex.
Dosing and Administration
- Dose: 30 mg, taken 1–3 hours before anticipated intercourse.
- Maximum Frequency: One dose per 24 hours.
Side Effects
- Dizziness
- Vomiting
- Fainting (Syncope)
- Hypotension
Contraindications
- Significant cardiac conditions.
- Hepatic impairment.
- Renal impairment.
- Concomitant use with antidepressants or drugs that may cause serotonin toxicity.
- Concomitant use with strong CYP3A4 inhibitors.
Alternative PE Treatment
Local anesthetics have also been used effectively to manage premature ejaculation.
Phosphodiesterase Type 5 (PDE5) Inhibitors
Common Side Effects of PDE5 Inhibitors
- Headache: Tadalafil-