Sterilization Process Validation: Physical, Chemical, and Biological Controls
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Sterilization Process Validation: Ensuring Effective Control
Objective: To ensure effective sterilization.
Physical Controls
Values of pressure, temperature, time, and humidity are monitored to ensure proper sterilization parameters are met.
Chemical Controls
Chemical controls are compounds that change color upon interaction with the sterilizing agent. External indicators show that the sterilizing agent reached the surface of the package. Internal indicators confirm whether the sterilizing agent penetrated inside the package. The Dick Bowie test, commonly used in autoclaves, uses paper impregnated with a compound that changes color upon successful sterilization. It is used daily to verify the device's functionality and the sterilizing agent's reach.... Continue reading "Sterilization Process Validation: Physical, Chemical, and Biological Controls" »