Peripheral Neuropathy: Causes, Classification, and Symptoms
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1. What Is Peripheral Neuropathy?
Peripheral neuropathy is a chronic disease characterized by varied sensory, motor, and autonomic symptoms. It often appears as a systemic illness, with complications linked to metabolic, toxic, infectious, nutritional, neoplastic, and immunologic factors.
2. What Is Axonal Degeneration?
In response to injury, nerves may undergo axonal degeneration. When the axon's continuity is interrupted, it loses its connection to the cell body and the ability to receive necessary nutrients. Consequently, the myelin bands degenerate secondarily.
3. What Is Demyelination?
Demyelination is a primary reaction where the myelin sheath degenerates. This process leads to:
- Slowing of nerve conduction
- Nerve conduction block
- Initiation of