Immune System Functions: Antigen Presentation and Cell Killing
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c) Antigen Processing and Presentation
- Engulf protein antigens, partially digest them, and display polypeptide fragments on the surface for T cells to "see."
- Fragments are associated on the surface with Major Histocompatibility Antigens (MHC II), which are necessary to activate T cells.
d) Dendritic Cell Migration
To increase the chance of interacting with the correct T cells, dendritic cells migrate to secondary lymphoid organs (chemokines are secreted to attract T cells).
VII. Extracellular Killing by the Immune System
A. Natural Killer (NK) Cells
NK cells lyse virus-infected cells, tumor cells, and parasites. They kill cells that do not express MHC class I antigens.
B. Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
- In ADCC, NK cells and macrophages