cell moles2
Classified in Biology
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Sliding filament model of contraction
1.ATP binds to a myosin head and forms ADP + P
2. Ca exposes the binding sites on the actin filaments
3.Cross bridges between myosin head and actin filaments form
4.ATP causes the cross bridges to unbind
Skeletal muscle contration
- Tropomyosin-->7 actin-binding sites to 7 actin monomers
In a thin filament
- Troponin-->complex of 3 subunits(TN-T,TN-I,TN-C-binds Ca)
presence of Ca & TN-->TM can occupy ON And OFF state
OFF -> no Ca ->TM blocks myosin interaction with F-actin
ON -> binding to Ca -> movement of TM exposing myosin binding sites on actin
Smooth muscle contraction -> different from skeletal because of the presence of calmodulin and myosin light chain kinase (MLK) that lead to contraction
Actin and myosin in non-muscle cells
1.Support-->to epithelial cells-->adherens Junctions-->circumferential belt
2.Cytokinesis-->cell division-->accumulates at the Equator
4.Cell adhesion-->contractile bundles(myosin II) -> adherens junctions
non-contractile bundles-->from the core of membrane Projections-->microvilli & filopodia
activity of myosin II was inhibited by deleting its gene or Injecting anti-myosin II antibodies into the cell-->a cell that lacked Myosin II was able to replicate its DNA and nucleus, but it didn't Divide-->a large & multinucleate cell
Membrane-bound myosin-->movement of vesicles
Myosin I & V-->move along actin filaments & carry Membrane vesicles
Myosin V-->transports from Golgi to cell periphery