Drug Absorption, Distribution, Metabolism, and Effects
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Intramuscular Drug Administration and Receptor Binding
Explains what a circuit is: a drug that is administered intramuscularly until it reaches the receptor. It exits the bloodstream through the capillary endothelium, traveling through the interstitial fluid, and crosses the cell membrane of its target cells.
Morphine Effects in Elderly Patients
Explains why an old man, who is administered morphine in doses equal to a middle-aged person, may be at increased risk of sleepiness, even after the drug's effects should have worn off. The elderly, like children, have decreased hepatic activity, so the drug takes longer to metabolize and be disposed of by the body, which can cause drowsiness in the case of morphine.