Metabolic Pathways and Energy Substrates in Human Tissues
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Heart Muscle
The heart is the ultimate aerobic tissue. Its activity depends heavily on glucose oxidation. It utilizes the following fuels and metabolic pathways:
- Glucose: Oxidation
- Fatty Acids: Beta-oxidation
- Ketone Bodies: Oxidation of acetoacetate
The heart also plays a role in the clearance of lactic acid produced by muscles.
Nervous System
The nervous system primarily utilizes:
- Glucose: Oxidation
- Ketone Bodies: Oxidation of acetoacetate
Adipose Tissue
Adipocytes serve as the body's energy reserves, storing free fatty acids as triacylglycerols. Because these cells lack the enzyme to catalyze the conversion of glycerol to glycerol-3-phosphate, they must utilize glucose.
Glucose concentration is a determinant factor in the esterification and release of... Continue reading "Metabolic Pathways and Energy Substrates in Human Tissues" »