Kartagener Syndrome: Causes, Symptoms, and Management
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Understanding Kartagener Syndrome
Kartagener syndrome is a rare genetic disorder, believed to follow an autosomal recessive inheritance pattern, with an incidence of approximately 1 in 20,000 live births.
Key Characteristics and Manifestations
This condition is one of the primary ciliary dyskinesia (PCD) syndromes, a group of disorders characterized by structural or functional alterations of cilia. These changes affect all ciliated epithelia in the body, including the respiratory epithelium (found in the sinuses and Eustachian tube) and sperm. This leads to impaired mucus clearance and retention.
Typically, Kartagener syndrome is characterized by a classic triad of symptoms:
- Situs Inversus (complete or partial): A rare anatomical abnormality where