It used to define the member functions of a class outside
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DESARROLLO INMUNOLOGY 2015
About the killing mechanism of Tc cells (the Kiss of death)
How would you define it?
It is a killing attack deliver by an armed cytotoxic T cell previously sensitize by the same antigen. A single Tc cell can attack many target cells (second amplification of the celular IR), we have to take into account that the contact between cells (during the Kiss of death) is very short in time. This attack ends with the death of infected cells.
How many activating signal needs a T cell to be able of delivering the Kiss of death. Explain details for each signal?
They need 3 signal:
1o→recognition of the appropiate peptide loaded onto a self HLA- class I molecule.2o→co-stimulatory signal delivered by CD28 bound to its ligand on