Antibody Reactions, Immune Response, and Immunologic Memory
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Antigen-antibody reactions
Ag + Ab AgAb
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·reversible reaction as there are formed noncovalently biochemical bonds
·strength of such interactions is called affinity
·different immunoglobulins within an individual show a wide range of affinity
·valence - number of epitope-binding sites of one immunoglobulin molecule
·avidity - describes the collective affinity of multiple binding sites (affinity + valence)
·e.g. although IgM has a low affinity, its avidity is quite high due to 10 epitope-binding sites
·...
Primary and secondary immune response
·primary immune response
ofirst contact to a foreign antigen that has to be eliminated from the body
ofirst a lag/induction phase (ca. 7-9 days or even up to months) occurs in which no antibody is produced,... Continue reading "Antibody Reactions, Immune Response, and Immunologic Memory" »