Understanding Hyperadrenalism and Related Syndromes

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Hypercorticosolism (Cushing Syndrome)


  • Cortisol-Secreting Adrenal Neoplasia
  • ACTH-Secreting ectopic Tumor
  • ACTH-Secreting Pituitary Adenoma (Cushing disease)

Cushing Syndrome:

  • sudden weight Gain
  • Truncal obesity
  • Buffalo hump
  • Moon Face
  • Abdominal Strain
  • Red Face Because BV become thinner closer to surface
  • Hypertension
  • Lab : Hypernitermeia, hypokalemia, Glucosuria
  • Low-Dose Dexamthasone Suppresion Test
  • (1 mg of dexamethasone @ 12 ... in the morning Dexamethsone should suppress ACTH and cortisol production = >120 mg
  • (In Cushing Cortisol Remains elevated)
min (10:20-11:30 )2-Find out where if we have Pituitary Adenoma will be if there is Suppresion of Cortisol in dexamethasone Suppresion Test !3- If there is No Response to Dexamthasone Test (-), CORTISOL Still HighACTH Secreting TumourAdrenal NeoplasiaAdrenal NEoplasia vs ACTH secreting Tumour:i-(ACTH Normal) ----------ACTH( High)

COnn Syndrome:

-Excess Secretion of Aldosteorne From the adrenal Glannd,-Ussual Cause Is Adenoma (
^Sx:-Hypertension-Weakness-Fatigue-polyuria-polydipsia-Headahce-Lab : hypernitremia, Hypokaemia
^Dx:-Aldosterone-To-Renin Ratio: 1-ARR >23.6 ------>primary Hyperaldosteronism-Abdominal CT-Lab: Hypernitremia & hypokalemia
-Removed adrenal Gland , Adrenalectomy

***Addison Syndrome:


-Loss of Cortisol ,hypocortisolism-Cause = ? or autoimmune-Acute Adrenal Insuff


-Salt Craving-Orthostatic Hypotension-weakness-weight loss-Increase skin pigmentation-Amenorrhea-BP slightly Lower-Lab:1-Hyponatremia & Hyperkalemia2-Metabolic Acidosis


-Stabilizing the Patient-Cosynotropin Stimulation Test


-Better preventive, keep patient out of adrenal crises-Replace GCD(cortisol ) and Minercorticoid(aldosterone)-To replace Mineralocorticoid we use Fludrocortisone-Increase prednisone if they become ill

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