Two-Compartment vs. One-Compartment IV Bolus Pharmacokinetics
Two-Compartment IV Bolus Model
The two-compartment intravenous (IV) bolus model describes the kinetics of drugs that do not distribute instantaneously throughout the body. Following rapid IV injection, drugs distribute quickly into a central compartment (blood/well-perfused tissues) and slowly into a peripheral compartment (tissues), displaying a biexponential plasma concentration decline over time.
Compartment Definitions
- Central Compartment (Vc): Blood and highly perfused tissues (liver, kidneys, heart). Elimination mainly occurs here.
- Peripheral Compartment (Vp): Poorly perfused or slowly equilibrated tissues (muscles, adipose, skin).
Biexponential Decline
The plasma level-time plot is not a straight line on a semi-log scale; it shows a rapid... Continue reading "Two-Compartment vs. One-Compartment IV Bolus Pharmacokinetics" »
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