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Understanding Cellular and Acquired Immunity: Types, Mechanisms, and Pathologies

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Cellular Immunity

Cellular immunity involves two main types of lymphocytes: T lymphocytes and B lymphocytes. It also involves non-T, non-B cells. This system effectively destroys:

  • Foreign cells
  • Tumor cells
  • Virus-infected cells
  • Cells infected by intracellular pathogens

T Lymphocytes

T4 Lymphocytes

TH Lymphocytes: These cells stimulate other T cells and B lymphocytes.

TD Lymphocytes: These cells increase the number and activity of macrophages.

T8 Lymphocytes

TC Lymphocytes: These cells destroy target cells.

TS Lymphocytes: These cells regulate and suppress excessive or inappropriate immune responses. They deactivate lymphocytes once antigenic agents are controlled.

A phagocyte captures a foreign element, digests it, and presents it as an antigen-presenting... Continue reading "Understanding Cellular and Acquired Immunity: Types, Mechanisms, and Pathologies" »

Neck and Pelvic Anatomy Essentials

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Neck Anatomy

The head and neck join the upper chest. The neck comprises skin, fibrous muscles, major vascular elements, lymph nodes, organs (cervical larynx, cervical trachea), and glands (thyroid and parathyroid).

The skeletal neck includes the cervical spine.

  • Platysma (2): Thin ring from the superclavicular zone to the face, deep chin.
  • Sternocleidomastoid (2): Lateral neck, from the thorax to the temporal and occipital mastoid bones.
    • Origin: Lower insertion and command of the sternum and below the clavicle.
    • Lateral/External: External jugular vein, ending with the subclavian, used for serum.
    • Medial/Internal: Vasculo-nervous bundle, primitive carotid artery, internal jugular vein, neurogastric nerve.
    • Double Innervation: Branches of the nerve cord and
... Continue reading "Neck and Pelvic Anatomy Essentials" »

Acute Renal Failure: Signs, Classification, and Diagnosis

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Acute Renal Failure (ARF)

Signs

ARF is often asymptomatic. However, some common signs include:

  • Oliguria: Urine output of less than 400 ml per day
  • Increased nitrogen products in the blood
  • Electrolyte and acid-base abnormalities

Classification of Acute Renal Failure

1. Pre-renal ARF

This type accounts for 55% of cases. It is characterized by a deficiency in kidney perfusion, which decreases the glomerular filtration rate (GFR). There is no frank damage to the renal parenchyma initially.

Features of Pre-renal ARF:

  • Often reversible
  • No initial damage to the renal parenchyma
  • Prolonged deficiency can lead to ischemia and acute tubular necrosis
  • The renal tubules and loop of Henle are most affected by ischemia

Phases of Pre-renal ARF:

  • Extension phase: Swelling occurs,
... Continue reading "Acute Renal Failure: Signs, Classification, and Diagnosis" »

Vertebrate Animals: Mammals, Birds, and Reptiles

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Mammals

  • Females have breasts that produce milk to feed their young.
  • The body is covered with hair.
  • Body temperature is constant.
  • Young are born alive.
  • Examples: Prototherians (e.g., the platypus), marsupials (e.g., kangaroos), and eutherians (e.g., insectivores, bats, primates, cetaceans, carnivores, Perissodactyla, and Artiodactyla).
  • Temperature: Mammals maintain a constant body temperature, typically between 38 and 40 degrees Celsius, regardless of whether they live in hot or cold climates.
  • Reproduction: Mammals reproduce viviparously with internal fertilization. They lay eggs without nutrient reserves, which are implanted and developed in the womb. The placenta provides nourishment and oxygen to the developing fetus and facilitates the excretion
... Continue reading "Vertebrate Animals: Mammals, Birds, and Reptiles" »

How Your Body Breathes and Uses Energy

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Cellular Respiration Explained

Respiration is the process in which glucose and oxygen are transformed inside the cell into water, carbon dioxide, and energy.

The goal is to transform glucose and oxygen into energy.

Gases involved are oxygen, which we use, and carbon dioxide, the result.

It happens inside the cell in the mitochondria.

Defining Metabolic Rate

Metabolic rate is an average of the amount of energy that a person needs. While sleeping, we spend energy in circulation, for development, breathing, and protection. We spend energy because the body is working constantly.

Function of the Breathing System

In breathing, gases are exchanged. Oxygen goes from the air to the blood, and carbon dioxide goes from the blood to the air.

Lining of the Respiratory

... Continue reading "How Your Body Breathes and Uses Energy" »

Understanding Neurons and Nervous Systems

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Neurons: The Basic Unit of the Nervous System

A neuron is the basic unit in the nervous system. It is a specialized conductor cell that receives and transmits electrochemical nerve impulses. A typical neuron has a cell body and long arms that conduct impulses from one body part to another.

Three Different Parts of the Neuron:

  • The cell body
  • Dendrites
  • Axon

Types of Neurons

  • Multipolar neurons have one axon and several dendrites. These are common in the brain and spinal cord.
  • Bipolar neurons have one axon and one dendrite. These are seen in the retina of the eye, the inner ear, and the olfactory (smell) area.
  • Unipolar neurons have one process extending from the cell body. The one process divides with one part acting as an axon and the other part functioning
... Continue reading "Understanding Neurons and Nervous Systems" »

Economic Entomology: Insect Ecology and Pest Management

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Economic Entomology

It refers to the study of all aspects of insects that are related in a way or another with human activity involving the economic, ecological and social.

Ecology of Insects

Species: A group of individuals who share common characteristics, can interbreed and produce fertile offspring under natural conditions.

Population: Group of organisms of the same species that occupy a certain space at a given time.

Community: A group of populations of several species of plants or animals that share a certain time regardless.

Ecosystem: Habitat where biotic and abiotic factors interact to exchange energy and matter in a continuous cycle.

Agroecosystem: Artificial system manipulated by man but stable in nature.

Ecological Niche: Resources that... Continue reading "Economic Entomology: Insect Ecology and Pest Management" »

Cerebral and Basilar Arteries: Anatomy and Venous System

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Cerebral and Basilar Arteries

The carotid artery supplies 80% of the oxygen to the cerebral hemispheres. The two internal carotid arteries branch into the middle cerebral arteries, which provide 60% of the brain's oxygen supply. The anterior communicating artery connects the right and left middle cerebral arteries.

Two vertebral arteries (left and right) ascend along the spinal cord and merge at the base of the skull to form the basilar artery. This artery supplies the medulla, pons, and other brainstem structures.

Circle of Willis

  1. Frontal lobes
  2. Temporal lobes
  3. Middle cerebral artery (right and left)
  4. Anterior cerebral artery
  5. Posterior cerebral artery
  6. Basilar artery
  7. Vertebral arteries (right and left)
  8. Spinal cord
  9. Internal carotid artery
  10. Anterior communicating
... Continue reading "Cerebral and Basilar Arteries: Anatomy and Venous System" »

Cell Division: Mitosis, Meiosis, and Mutations Explained

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Cytokinesis

Cytokinesis begins in anaphase and continues through telophase.

  • In animals: The process involves strangling the cytoplasm. Segmentation is a linear division, resulting in the formation of a contractile ring formed by actin filaments.
  • In plants: The cell wall prevents segmentation. This is done by forming a new wall inside the cell. This new wall is formed at the equator by the association of Golgi apparatus vesicles and microtubules, and it is called a phragmoplast. It extends laterally to reach the cell wall.

Types of Cell Division

  1. Bipartition

    Division of the cell. Two daughter cells originate, equal in size. The process involves karyokinesis and cytokinesis, with its variant being strangulation.

  2. Multiple Fission

    Divisions of the cell.

... Continue reading "Cell Division: Mitosis, Meiosis, and Mutations Explained" »

Understanding Key Health Concepts: A Concise Overview

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Understanding Key Health Concepts

1 - Life expectancy is the average number of years a person born in a particular country in a specific year is expected to live, assuming mortality rates remain constant.

2 - According to the WHO, health can be defined as: "A state of complete physical, mental, and social well-being, and not merely the absence of disease or infirmity."

3 - CVD stands for cardiovascular diseases, which affect the heart or blood vessels.

4 - Myocardial infarction, a type of coronary heart disease (CHD), results in the death of myocardial tissue and permanent damage to the heart muscle. Angina pectoris occurs when a partial blockage reduces blood flow to an area of the heart, causing pain but not irreversible damage. Heart attacks... Continue reading "Understanding Key Health Concepts: A Concise Overview" »