Drug Administration Routes: Bioavailability and Safety Insights
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Oral Drug Bioavailability: Unpredictable Factors
The bioavailability of oral drugs can be unpredictable because drug absorption depends on many factors, including:
- Gastrointestinal functional status: How well the digestive system is working.
- Food intake: Presence or absence of food can affect absorption rates.
- pH level: The acidity or alkalinity within the gastrointestinal tract.
Sublingual Drug Administration: Key Benefits
The sublingual route is particularly useful for certain drugs, such as nitroglycerin, for two main reasons:
- It allows for rapid administration in emergency situations.
- It bypasses first-pass metabolism in the liver. Drugs that are extensively metabolized in the liver may not reach therapeutic plasma levels if administered orally.