Notes, summaries, assignments, exams, and problems for Biology

Pulmonary Gas Exchange Physiology

Gaseous diffusion: Gas exchange is performed in the alveoli across the alveolar–capillary membrane. Oxygen moves from the air inside the alveoli into the pulmonary capillary blood across this membrane; carbon dioxide moves in the opposite direction. This diffusion occurs while oxygenates blood flows through the pulmonary capillaries and air fills the alveolar spaces.

Transport of Gases

Gases exchanged in the circulation are transported either bound to hemoglobin or dissolved in plasma in small quantities. Hemoglobin binding accounts for the majority of oxygen transport in blood.

Cellular Respiration

Oxygen passes from the capillaries into the cells, and carbon dioxide passes from the cells into the capillaries,... Continue reading "Pulmonary Gas Exchange and Common Lung Diseases" »

Biomolecules and Genetic Information

Biomolecules form long chains, such as in genetic information storage. These chains consist of repeating nucleotides. A nucleotide is composed of a nitrogenous base, a pentose sugar (like am5C), and a phosphate group. A nucleoside is simply a base plus a pentose sugar.

Nitrogenous bases include adenine (A), thymine (T), uracil (U), and guanine (G). Purine bases (A and G) have a two-ring structure, while pyrimidine bases (C, T, and U) have a single-ring structure. These bases contain the genetic code necessary for protein synthesis. Approximately 3000 base pairs are needed to code for a single protein. The human genome contains 46 chromosomes (23 pairs), with 22 pairs being autosomes and one pair being sex... Continue reading "Biomolecules, Genetics, and Chromosomal Variations" »

Factors Affecting Enzyme Activity

pH Effects on Enzyme Function

Enzymes exhibit an optimum pH at which their activity is maximal, characterized by a low K_m (substrate concentration) and maximum velocity. Small variations around this optimum pH value cause a sudden drop in activity. This can be due to the appearance or disappearance of electrostatic forces that alter the spatial structure of the active site, or changes in the charges of the active center and substrate, which affect their binding capacity. If the pH change is very high, the enzyme is denatured and ceases to be functional.

Temperature's Role in Enzyme Kinetics

In general, an increase in temperature increases the rate of chemical reactions. In the case of enzyme-catalyzed reactions,... Continue reading "Enzyme Activity: Factors, Inhibition, and Metabolic Control" »

Macrophages and Their Functions

Macrophages originate from blood monocytes and form in the tonsils, spleen, and lymphatic vessels. They then migrate to different tissues where they are given different names. They release a substance (interleukin 1) which behaves as a second messenger that acts on the hypothalamus by altering its thermostatic function and resetting it to a higher level, causing a temperature rise. This increase stimulates the activity of leukocytes (white blood cells) and decreases the amount of iron (Fe) in the blood, which is an essential element for bacterial growth.

The Inflammatory Response Mechanism

The Inflammatory Response is a local reaction caused by the penetration of pathogens. It involves the connective tissue, blood... Continue reading "Immune System Components and Mechanisms" »

Arthropods

Arthropods: abundant, well-known species (flies, crabs) and representatives in virtually all habitats.

Body plan

The arthropod body plan is based on several key features:

• Body segmented: segments are grouped into regions, such as head and abdomen.
• Exoskeleton: strong and flexible due to chitin; arthropods molt to grow — they emerge from the old exoskeleton and secrete a new one.
• Jointed appendages: some appendages are walking legs, others serve sensory or feeding functions.

Major groups

Characteristics of the major groups of arthropods:

• Arachnids (spiders, scorpions)
• Crustaceans (crabs, shrimp)
• Insects (flies, beetles, butterflies)
• Myriapods (centipedes, millipedes)

Echinoderms

Echinoderms: sea animals such as starfish and sea urchins. They... Continue reading "Animal Phyla and Vertebrate Classes: Arthropods to Mammals" »

Fertilization Process

Ovulation occurs about fourteen days before menstruation. The egg released from the Graafian follicle is propelled along the fallopian tube to the uterus, taking over a week for this journey.

The egg can be fertilized for only 24 hours after ovulation while traveling along the fallopian tube.

Intercourse, or the sexual act, is the introduction of the penis into the vagina. At ejaculation, sperm are released inside the vagina.

Unlike the egg, sperm are very fast. They ascend through the vagina, traverse the cervix and uterus, and reach both fallopian tubes in a few hours. They can also survive for three to five days, so if intercourse occurs in the days before ovulation, the probability of pregnancy is very high.

If the egg... Continue reading "Fertilization and Early Pregnancy Stages" »

Key Concepts in Health and Disease

Risk Factor

A risk factor is any circumstance or detectable characteristic in a group of persons related to the probability of developing or producing disease.

Public Health

Public health involves the application of the scientific method to problems of health and disease, considered as a subject for the community.

Preventive Medicine

Preventive medicine is a branch of medicine dealing with preventing, on the individual, family, or population group level, the appearance, development, and maintenance of disease, based on the knowledge of medical science.

Disease

Disease is a physical or mental disorder that causes alterations in the normal functioning of the body, whether at the physical or mental level.

Pathology

Pathology... Continue reading "Understanding Disease Factors and Medical Terminology" »

Fundamentals of Amino Acids and Protein Structure

Defining Amino Acids (AA)

Amino acids (AA) are organic compounds characterized by the presence of both an amino group (-NH₂) and a carboxyl group (-COOH). There are 20 standard amino acids. We cannot metabolize the essential amino acids, meaning they must be obtained through the diet.

Classification of Amino Acid Side Chains

Amino acids are classified based on the properties of their side chain (R group):

• Nonpolar (Hydrophobic): R group is hydrophobic and typically located on the exterior in aqueous environments.
• Polar Ionizable: R group is polar and located internally.
• Polar Acids: R group contains an additional carboxyl group, located internally.
• Polar Basic: R group contains an additional amino

DNA Replication

DNA replication begins with the double helix unwinding, separating like a zipper. Each strand serves as a template for creating a new complementary strand. DNA polymerase enzymes add nucleotides one by one, matching adenine with thymine and guanine with cytosine. This process creates two identical DNA molecules, each with one original and one new strand. Errors during replication can lead to mutations, which can be harmless, cause diseases, or contribute to evolution.

The Importance of Base Complementarity

Base complementarity is crucial for accurate DNA replication, ensuring that genetic information is passed correctly from parent to daughter cells. It also forms the basis of many molecular biology techniques.

Gene Expression:

Understanding Diet and Health Conditions

Essential Dietary Concepts

• Balanced Diet: Consuming the correct nutrients in the appropriate proportions for optimal health.
• Malnutrition: A condition occurring when either too much or too little of a nutrient is consumed, leading to health problems.
• Kwashiorkor: A severe form of malnutrition caused by insufficient protein intake, primarily affecting children and leading to poor growth and development.
• Myocardial Infarction (Heart Attack): Occurs when a part of the heart's wall dies due to lack of blood supply.

Obesity and Associated Health Risks

• Causes of Obesity: Primarily results from consuming too much fat and calories.
• Health Complications: Obesity is a significant health problem, contributing to conditions