Allergic and Immune Hypersensitivity Reactions: Types I & II
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Type I Hypersensitivity Reactions: Immediate Allergic Responses
These are the most common type of allergic reactions. They are mediated by Immunoglobulin E (IgE) antibodies, which are primarily located on mast cells found in various tissues throughout the body. The reaction between an antibody (Ab) and an antigen (Ag), also known as an allergen in this context, triggers a cascade of responses that can sometimes lead to tissue damage.
Phases of Type I Hypersensitivity
Type I hypersensitivity reactions occur in two distinct phases:
- Immediate Phase: Mediated primarily by histamine, leading to rapid symptoms.
- Late-Phase Reaction: Mediated by other compounds such as Leukotriene C4 (LTC4) and Prostaglandin D2 (PGD2), which have similar inflammatory effects