Notes, summaries, assignments, exams, and problems for Biology

Week 1: The Heart

Purpose of the Cardiovascular System

To provide adequate blood flow to all tissues/organs according to immediate needs.

Heart Contractions

• Systole: Periods of contraction
• Diastole: Periods of relaxation

Note: The atria contract simultaneously, followed by simultaneous ventricular contraction.

Blood Vessels

• Arteries: Carry blood away from the heart.
• Veins: Carry blood towards the heart.

Intrinsic Conduction System

1. Sinoatrial (SA) Node (Pacemaker): Generates impulses in the right atrial wall. Depolarizes 80-100 times per minute, modified by the autonomic nervous system to approximately 75 times per minute.
2. Atrioventricular (AV) Node: Impulses pause here for 0.1 seconds, allowing the atria to complete contraction. Generates impulses 40-60

Cells are open systems – they exchange both matter and energy with their environment.

Cellular Open Systems: Examples of Exchange

• In: Water, oxygen, nutrients, solar energy (in plants)
• Out: Carbon dioxide, waste, thermal energy, kinetic energy

Cellular Needs and Organ System Functions

Surface Area to Volume Ratio (SA:V)

Cells work best with a high SA:V ratio (more membrane per unit of volume).

• Small cells = high SA:V → efficient transport
• Large cells = low SA:V → less efficient

SA:V Ratio Calculation Formulas

• Surface Area of cube:

Lymphocyte Migration and Immune Response

Lymphocytes constantly migrate through the blood and lymph, moving from one lymphoid organ to another. This process:

• Enhances the chance that an antibody will encounter its specific antigen.
• The spleen filters blood, while other lymphoid organs filter lymph.

Phagocytosis: A Non-Specific Innate Immune Response

Phagocytosis is the ingestion of microorganisms or particulate matter by a cell. It is performed by phagocytes, which are certain types of white blood cells or their derivatives.

Actions of Phagocytic Cells

1. Among the granulocytes, neutrophils are the most important phagocytes.
2. Enlarged monocytes transform into wandering macrophages and fixed macrophages.
3. Fixed macrophages are located in selected tissues

Local Inflammation

1. Occurs when bacteria enter a break in the skin.
2. Inflammatory reaction is initiated by nonspecific mechanisms of phagocytosis and complement activation.
3. Complement activation attracts phagocytes to the area.
4. As inflammation progresses, B cells produce antibodies against bacterial antigens.
5. Attachment of antibodies to antigens amplifies nonspecific responses because of complement activation.
6. Promotes phagocytic activity of neutrophils, macrophages, and monocytes (through opsonization).
7. In the inflamed area, leukocytes attach to the surface of endothelial cells.
8. Move by chemotaxis to the inflamed site.

• Neutrophils arrive first, then monocytes, then T cells.
  • Undergo extravasation (the entire process of movement of leukocytes from the bloodstream

Nervous and Endocrine Systems

The nervous system receives external and internal stimuli, interprets them, and decides an appropriate response. The response is executed by the effector organ or tissue. Nervous tissue is made up of cells called neurons.

Stimulus → Nervous System → Effectors → Muscles, Glands

Neuron Structure

• Cell body: The central part of the neuron.
• Dendrites: Extensions of the cell body. They receive the nerve impulse and transmit it to the cell body.
• Axon: A long fiber extending from the cell body. It transmits the nerve impulse to other neurons or effector cells.
• Myelin sheath: This layer protects the axon and increases the speed of the nerve impulse.
• Axon terminals: These are located at the end of the axon. They contain neurotransmitters,

Human Energy: The Aerobic Advantage

Humans, as members of the Animal Kingdom, primarily utilize aerobic cellular respiration for energy production. This vital process involves our cells using oxygen to efficiently break down glucose (sugar) into ATP, the fundamental energy currency our bodies require. This intricate process occurs within the mitochondria, famously known as the "powerhouse" of the cell.

Humans demand substantial energy for movement, cognitive functions, and growth, making aerobic respiration perfectly suited for our active lifestyle. Our ancestors similarly required high energy levels for hunting, long-distance travel, and complex thought, which likely explains our evolutionary reliance on this efficient method. The complete pathway,... Continue reading "Cellular Respiration: Fueling Life and Classifying Organisms" »

Anatomy, Pathology, and Lab Essentials

Bones: Rigid organs that make up the skeletal system of vertebrates, providing support and protection for the body’s organs.

Cranium: The part of the skull that protects the brain.

Backbone: Also known as the spine or vertebral column, a flexible and strong structure running along the center of the back, made up of small bones called vertebrae.

Skull: A bony framework enclosing the brain of a vertebrate.

Joints: The points where two or more bones, or a bone and cartilage, are attached in the body.

Ligaments: Short bands of tough, flexible fibrous connective tissues that connect two bones or cartilages, or hold joints together.

Cartilage: Firm, flexible connective tissue found in various forms, from which the... Continue reading "Anatomy, Pathology, and Lab Essentials: A Comprehensive Glossary" »

The Human Respiratory System

By Marco Rios

Ventilation: Air Movement in the Lungs

Pulmonary Ventilation

The total volume of air breathed in and out per minute.

Alveolar Ventilation

The volume of air exchanged between the atmosphere and the alveoli per minute.

The Lungs: Core Organs of Respiration

A pair of organs consisting of the lower part of the respiratory airways, pulmonary circulation, and connective tissue.

Pleural Sacs and Cavity

Thin, fluid-filled membranes that enclose the lungs. The space between the pair is known as the pleural cavity.

Alveolar Cell Types

Type I Cells

Form the walls of the alveoli, facilitating gas exchange.

Type II Cells

Secrete pulmonary surfactant.

Pulmonary Surfactant

A substance that reduces the surface tension of water inside... Continue reading "Human Respiratory System Functions" »

Carbohydrates: Structure and Classification

Classification

• Monosaccharides: Single sugar unit (e.g., glucose, fructose).
• Disaccharides: Two sugar units joined (e.g., sucrose = glucose + fructose).
• Polysaccharides: Many sugar units linked (e.g., starch, glycogen).

Aldose vs. Ketose

• Aldose: Contains an aldehyde (-CHO) group (e.g., glucose).
• Ketose: Contains a ketone (>C=O) group (e.g., fructose).
• Number of Carbons: Triose (3C), Tetrose (4C), Pentose (5C), Hexose (6C).

Structural vs. Stereoisomers

• Structural Isomers: Same molecular formula, different bonding patterns or structure.
• Stereoisomers: Same connectivity, different spatial arrangement of atoms.

Chiral Carbons

• Chiral Carbon: A carbon atom bonded to four different groups, creating an asymmetric center.

Most living things obtain their energy either directly or indirectly from the energy of sunlight captured through photosynthesis.

Photosynthesis in 2 Stages

1. Pigments in the leaves' cells (chlorophyll) capture or absorb the sun's energy, which is used to power the second stage. The leaf cells also need water (absorbed through roots) and carbon dioxide (that enters through small openings on the undersides of leaves called stomata).
2. Inside the chloroplasts, water and carbon dioxide are transformed into glucose and oxygen. Plants use glucose for food and store what they don't need as starch (energy for later use) and cellulose (that makes up the cell walls). Oxygen and water exit the leaf through the stomata.

Stomata

Carbon dioxide enters the plant... Continue reading "Photosynthesis and Cellular Respiration in Plants" »