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Understanding Local Inflammation and Fever Response

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Local Inflammation

  1. Occurs when bacteria enter a break in the skin.
  2. Inflammatory reaction is initiated by nonspecific mechanisms of phagocytosis and complement activation.
  3. Complement activation attracts phagocytes to the area.
  4. As inflammation progresses, B cells produce antibodies against bacterial antigens.
  5. Attachment of antibodies to antigens amplifies nonspecific responses because of complement activation.
  6. Promotes phagocytic activity of neutrophils, macrophages, and monocytes (through opsonization).
  7. In the inflamed area, leukocytes attach to the surface of endothelial cells.
  8. Move by chemotaxis to the inflamed site.
  • Neutrophils arrive first, then monocytes, then T cells.
    • Undergo extravasation (the entire process of movement of leukocytes from the bloodstream
... Continue reading "Understanding Local Inflammation and Fever Response" »

Nervous and Endocrine Systems: Functions and Parts

Classified in Biology

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Nervous and Endocrine Systems

The nervous system receives external and internal stimuli, interprets them, and decides an appropriate response. The response is executed by the effector organ or tissue. Nervous tissue is made up of cells called neurons.

Stimulus → Nervous System → Effectors → Muscles, Glands

Neuron Structure

  • Cell body: The central part of the neuron.
  • Dendrites: Extensions of the cell body. They receive the nerve impulse and transmit it to the cell body.
  • Axon: A long fiber extending from the cell body. It transmits the nerve impulse to other neurons or effector cells.
  • Myelin sheath: This layer protects the axon and increases the speed of the nerve impulse.
  • Axon terminals: These are located at the end of the axon. They contain neurotransmitters,
... Continue reading "Nervous and Endocrine Systems: Functions and Parts" »

Anatomy, Pathology, and Lab Essentials: A Comprehensive Glossary

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Anatomy, Pathology, and Lab Essentials

Bones: Rigid organs that make up the skeletal system of vertebrates, providing support and protection for the body’s organs.

Cranium: The part of the skull that protects the brain.

Backbone: Also known as the spine or vertebral column, a flexible and strong structure running along the center of the back, made up of small bones called vertebrae.

Skull: A bony framework enclosing the brain of a vertebrate.

Joints: The points where two or more bones, or a bone and cartilage, are attached in the body.

Ligaments: Short bands of tough, flexible fibrous connective tissues that connect two bones or cartilages, or hold joints together.

Cartilage: Firm, flexible connective tissue found in various forms, from which the... Continue reading "Anatomy, Pathology, and Lab Essentials: A Comprehensive Glossary" »

Biochemistry Essentials: Carbohydrates, Lipids, and Proteins

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Carbohydrates: Structure and Classification

Classification

  • Monosaccharides: Single sugar unit (e.g., glucose, fructose).
  • Disaccharides: Two sugar units joined (e.g., sucrose = glucose + fructose).
  • Polysaccharides: Many sugar units linked (e.g., starch, glycogen).

Aldose vs. Ketose

  • Aldose: Contains an aldehyde (-CHO) group (e.g., glucose).
  • Ketose: Contains a ketone (>C=O) group (e.g., fructose).
  • Number of Carbons: Triose (3C), Tetrose (4C), Pentose (5C), Hexose (6C).

Structural vs. Stereoisomers

  • Structural Isomers: Same molecular formula, different bonding patterns or structure.
  • Stereoisomers: Same connectivity, different spatial arrangement of atoms.

Chiral Carbons

  • Chiral Carbon: A carbon atom bonded to four different groups, creating an asymmetric center.
... Continue reading "Biochemistry Essentials: Carbohydrates, Lipids, and Proteins" »

Photosynthesis and Cellular Respiration in Plants

Classified in Biology

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Most living things obtain their energy either directly or indirectly from the energy of sunlight captured through photosynthesis.

Photosynthesis in 2 Stages

  1. Pigments in the leaves' cells (chlorophyll) capture or absorb the sun's energy, which is used to power the second stage. The leaf cells also need water (absorbed through roots) and carbon dioxide (that enters through small openings on the undersides of leaves called stomata).
  2. Inside the chloroplasts, water and carbon dioxide are transformed into glucose and oxygen. Plants use glucose for food and store what they don't need as starch (energy for later use) and cellulose (that makes up the cell walls). Oxygen and water exit the leaf through the stomata.

Stomata

Carbon dioxide enters the plant... Continue reading "Photosynthesis and Cellular Respiration in Plants" »

Echinoderms & Arthropods: Morphology, Features, and Biology

Classified in Biology

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Echinoderms

Phylum: Echinodermata

  • Sea stars (starfish)
  • Sea urchins
  • Sand dollars
  • Sea cucumbers
  • Brittle stars

Key Features:

  • Symmetry: Larvae: Bilateral; Adults: Pentaradial
  • Body Covering: Spiny skin, endoskeleton made of calcium carbonate
  • Movement: Tube feet powered by water vascular system
  • Nervous System: No brain; nerve ring with radial nerves
  • Circulation: Water vascular system (no true circulatory system)
  • Respiration: Diffusion via tube feet or skin gills
  • Reproduction: Mostly external fertilization; can regenerate lost parts
  • Habitat: Marine only (no freshwater/terrestrial species)

Water Vascular System

A hydraulic system for movement, feeding, and respiration.

Frequently Asked Questions
  1. What type of symmetry do adult echinoderms have? Pentaradial symmetry
  2. Which
... Continue reading "Echinoderms & Arthropods: Morphology, Features, and Biology" »

Understanding Human Nutrition: Digestive System Essentials

Classified in Biology

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Human Nutrition: The Digestive System

Human nutrition involves several key systems: digestive, respiratory, circulatory, and excretory.

Preparation for Digestion

This phase consists of three main parts:

Insalivation

Insalivation involves saliva, a watery substance containing amylase enzymes that break down simple carbohydrates. Saliva is produced in three salivary glands: sublingual, submandibular, and parotid. The tongue, a muscular organ covered in taste buds, helps mix food with saliva, allowing us to taste food.

Mastication

Mastication consists of breaking down food into smaller pieces to ease digestion. Types of teeth include incisors, canines, molars, and premolars. Humans have 20 milk teeth and 32 adult teeth.

Swallowing

Swallowing involves two... Continue reading "Understanding Human Nutrition: Digestive System Essentials" »

Human Body Systems: Excretion, Digestion, and Immunity

Classified in Biology

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Human Body Systems and Excretion

Tissues/Organs/Organ System

Function in Excretion

Digestive System

Removal of faeces

Respiratory System

Removal of CO2 (alveoli)

Skin (sweat glands)

Removal of sweat and toxins

Urinary System

Blood filtration (Urine)

Absorption vs. Assimilation

Compare and contrast

Absorption and Assimilation

  • Similarity: Both involve nutrients—absorption transfers them into the bloodstream, and assimilation uses them in cells.

  • Difference: Absorption happens in the digestive system; assimilation occurs in tissues.

Digestion vs. Nutrition

Digestion and Nutrition

  • Similarity: Both are essential for energy and growth—digestion breaks down food, and nutrition provides the substances needed for this process.

  • Difference: Digestion is the physical

... Continue reading "Human Body Systems: Excretion, Digestion, and Immunity" »

Infrared Spectroscopy of Organic Compounds: A Comprehensive Guide

Classified in Biology

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Infrared Spectra of Alkanes

Alkanes, being saturated hydrocarbons, only contain Carbon-Carbon (C-C) and carbon-hydrogen single bonds. Their IR spectra are relatively simple due to the absence of strong functional groups.

C-H Stretching

The most prominent peaks in an alkane's IR spectrum are due to C-H stretching vibrations. These sharp, strong bands typically appear in the range of 2850-2960 cm-1. The exact wavenumber can vary slightly depending on the specific alkane and its branching.

Infrared Spectra of Alkenes

Alkenes contain at least one carbon-carbon double bond (C=C), along with C-H bonds. The presence of the double bond introduces distinct features in their IR spectra compared to alkanes.

C=C Stretching

The stretching vibration of the C=C... Continue reading "Infrared Spectroscopy of Organic Compounds: A Comprehensive Guide" »

Endodontic Surgery and Root Canal Procedures

Classified in Biology

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Steps in Root End Surgery

  • Local anesthesia and hemostasis
  • Management of soft tissue
  • Management of hard tissue
  • Surgical access (visual and operative)
  • Access to root structure
  • Periradicular curettage
  • Root end resection
  • Root end preparation
  • Root end filling
  • Soft tissue repositioning and suturing
  • Post-surgical care

Root End Preparation

Preparing a cavity to receive root end filling.

According to Carr and Bentkover, this involves a Class I preparation at least 3mm into root dentin with walls parallel to and coincident with the anatomic outline of the pulp space.

Key requirements:

  1. The apical 3mm of the root canal must be freshly cleaned and shaped.
  2. The preparation must be parallel to and coincident with the anatomic outline of the pulp space.
  3. Adequate retention form
... Continue reading "Endodontic Surgery and Root Canal Procedures" »