Understanding Local Inflammation and Fever Response
Classified in Biology
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Local Inflammation
- Occurs when bacteria enter a break in the skin.
- Inflammatory reaction is initiated by nonspecific mechanisms of phagocytosis and complement activation.
- Complement activation attracts phagocytes to the area.
- As inflammation progresses, B cells produce antibodies against bacterial antigens.
- Attachment of antibodies to antigens amplifies nonspecific responses because of complement activation.
- Promotes phagocytic activity of neutrophils, macrophages, and monocytes (through opsonization).
- In the inflamed area, leukocytes attach to the surface of endothelial cells.
- Move by chemotaxis to the inflamed site.
- Neutrophils arrive first, then monocytes, then T cells.
- Undergo extravasation (the entire process of movement of leukocytes from the bloodstream