Cell Biology: ECM Components and Transport Mechanisms
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Extracellular Matrix and Cell Adhesion
Key Components of the ECM
- Glycosaminoglycans (GAGs) are highly negatively charged polysaccharides that attract counterions and water, forming hydrated gels that resist compression and permit diffusion.
- Proteoglycans contain GAG chains attached to core proteins and contribute to this hydrated ECM.
- Multiadhesive proteins, such as fibronectin and laminin, bind multiple partners, including ECM components and cell-surface receptors.
- Integrins bind these adhesive proteins and connect the ECM to the cytoskeleton, allowing for adhesion, migration, force transmission, and bidirectional signaling.
The Process of Leukocyte Extravasation
- Leukocyte extravasation occurs through a sequence of rolling, activation, firm adhesion,