Notes, summaries, assignments, exams, and exercises for Biology for Baccalaureate

Cellular Structures, Metabolism, and Reproduction Processes

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Cellular Biology Fundamentals

Cell Types

  • Prokaryotic Cells

    Single-celled organisms. They possess a cell wall and plasma membrane but lack a true nucleus. DNA is scattered throughout the cytoplasm, and they contain ribosomes.

  • Eukaryotic Cells

    Have a true nucleus and organelles dispersed in the cytoplasm. They can be unicellular or multicellular.

Cellular Structures and Organelles

Cell Wall

Provides protection and form, primarily found in plant cells.

Plasma Membrane

Regulates the entry and exit of substances into cells (found in plant and animal cells).

Nucleus

Controls and directs the functions and division of cells (plant and animal).

Cytoplasm

Contains cellular organelles and is the medium where metabolic reactions occur (plant and animal).

Mitochondria

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Carbohydrates, Lipids and Proteins: Structure and Functions

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Carbohydrates

Carbohydrates: compounds composed of carbon, hydrogen and oxygen, comprising sugars and derived substances.

Types

Monosaccharides and soluble disaccharides: sweet-tasting, soluble in water, crystalline solids, etc.

Functions

  1. Energetic: constitute the main source of glucose energy.
  2. Structural: part of structural polysaccharides in the skeleton.

Lipids

Lipids: compounds of C, H and O, also P, K and S. Common characteristics: oily, insoluble in water, soluble in organic solvents.

Classification

Saponifiable: lipids that originate esters that can be hydrolyzed. They are classified as:

  • Acylglycerols: glycerol esters with 2 or 3 fatty acid molecules.
  • Ceride: esters of monoalcohols and fatty acids.
  • Phosphoglycerides: composed of glycerol, fatty acids,
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Immune System Fundamentals: Key Concepts

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Antibody: Structure and Function

Molecules manufactured by B lymphocytes in response to contact with an antigen. Chemically, they are globular plasma proteins that detect and specifically bind to the antigen, leading to the humoral immune response. This allows them to detect and neutralize or bind to microorganisms that are then phagocytosed by macrophages.

Antigen: Immune System Trigger

A molecule capable of triggering an immune response. These molecules are foreign; the immune system does not recognize them as its own. They are detected by antibodies. Antigens are macromolecules of protein or polysaccharide nature.

Autoimmunity: Immune System Error

This occurs when the immune system synthesizes antibodies against the organism itself. It is an...

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Immune System Functions, Cells, and Defense Mechanisms

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Immunology and the Immune System

Immunology studies the processes involved in recognition and rejection of foreign substances or potentially harmful organisms. The immune system is the complex set of defense mechanisms that allow living things to protect themselves.

Antigen Definition

Antigen: a molecule, often located outside a cell or organism, which is recognized as foreign and that induces an immune response.

The Immune System Components

The immune system comprises leukocytes and antibodies.

The Body's Defenses

  • Structural: skin and mucous membranes
  • Mechanical: cilia of the respiratory tract, urinary and digestive movements
  • Biochemical: HCl in gastric juice; lysozyme in tears, saliva, and urine
  • Ecological: commensal microorganisms

Unspecific (Innate)

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Human Health: Diseases, Immunity, and Prevention

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Understanding Health & Disease

Health initiatives are often geared toward reducing exposure to various factors that are carcinogens, such as alcohol, tobacco, and diet. Recent years have spawned a new area of scientific knowledge: epigenetics, which studies the influence of the environment on gene expression.

Mental Health Conditions

Some diseases of the nervous system are due to malfunctioning neurons or injuries provoked by varied causes, such as high blood pressure, strokes, or lack of blood supply. The most important mental health challenges include:

  • Depression

    Characterized by deep sadness and an incapacity to lead a normal life.

  • Schizophrenia

    A disease that can present from adolescence, provoking serious personality disorders and disconnecting

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DNA Structure, Genetic Engineering, and Stem Cell Applications

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DNA Structure and Function

DNA is a large molecule formed by the union of simpler molecules called nucleotides. They are composed of phosphoric acid, deoxyribose, and a nitrogenous base (adenine (A), guanine (G), cytosine (C), or thymine (T)).

DNA consists of two long chains of nucleotides twisted into a double helix. Adenine joins with Thymine (with double hydrogen bonds), and Guanine joins with Cytosine (with triple hydrogen bonds).

Molecular Tools in Genetics

Cellular enzymes are used to cut and join fragments of DNA within cells. Restriction enzymes are responsible for "cutting" the DNA, and ligases unite the fragments.

Cloning DNA Technology

DNA Cloning Process

Cloning a DNA fragment consists of obtaining billions of identical copies of that...

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The Fundamentals of Virus Morphology and Replication

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Viral Morphology

The morphology of the virion capsid is defined by its composition of multiple copies of a single protein or several different proteins, each encoded by a viral gene. A capsid, along with the nucleic acid it contains, is called a nucleocapsid. Virions exhibit two primary types of symmetry: helical and icosahedral.

Symmetry Types

Helical Symmetry

This is a helical protein structure with RNA or DNA protected inside it.

Icosahedral Symmetry

An icosahedral virus is a polyhedron composed of 20 identical, equilateral triangular faces.

In some viruses, the nucleocapsid is coated by an outer shell, or envelope, which is a fragment of the host cell's plasma membrane acquired as the virus emerges through a process called budding.

Complex Structures

Some...

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Central Dogma: Molecular Mechanisms of Life

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Central Dogma of Molecular Biology

The schema describes the basic functional relationships between DNA, RNA, and proteins. In essence, DNA provides a model for its own replication and transcription. RNA is translated into proteins, formed under the encoding determined by its nucleotide triplets.

Watson-Crick Hypothesis (1953)

The two strands are separated, and from each, according to the rules of base complementarity, the respective complementary strands will be constructed.

Meselson-Stahl Experiment (1957)

Bacteria are grown with N15 (heavy nitrogen) and separated by centrifugation in a medium with a density gradient.

Key Features of DNA Replication

  • It is semiconservative.
  • It is a complex process that involves many enzymes.
  • It is a two-way process.
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Characteristics of Eukaryotic and Prokaryotic Life Forms

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Eukaryotes

The term Eukaryote comes from the Latin eu (good or true) and karyon (nucleus).

  • These are cells possessing a true nucleus and a cell membrane. The DNA is contained within chromosomes inside the nucleus.
  • They are generally large cells, ranging from 10 to 100 microns. While a few are unicellular or colonial, most form multicellular tissues.
  • Reproduction is either asexual or sexual, with cell division occurring via mitosis. They possess a mitotic spindle or some form of microtubule-based organization.
  • Eukaryotes are strictly aerobic for gas exchange with the environment, although some, like yeast, perform anaerobic fermentation.
  • They feature cytoplasmic organelles, such as vacuoles, mitochondria, endoplasmic reticulum, and the Golgi apparatus.
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Protein Structure: From Primary Sequence to Quaternary Complexity

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Protein Structure
Primary Structure: The primary structure is the sequence of amino acids joined by peptide bonds. These radicals are arranged alternately on either side.
Secondary Structure:
-Alpha-helix Structure: This is a structural complication of the primary structure, resembling a helix. The links that rotate the structure are non-peptidic. It was formed in two phases:
1. There is a shift from one plane to another, similar to a door opening, approximately 100 degrees.
2. There is a 180-degree rotation around an axis located in the central part of the plane. This movement leaves the plane in an inverted position, higher than the anterior plane.
These two movements are simultaneous, and their repetition forms a double alpha-helix. All oxygen...

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