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Cell Biology: Actin, Myosin, and Microtubules

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Polymerization –plus and minus ends of actin, Kd, critical concentration, phases of growth of polymers (lag, growth, and steady-state), nucleating factors, why growth occurs preferentially at plus end.

a.High Kd and Cc= ADP + Factin lower affinity actin so dissociate

b.Lower kd and Cc= Gactin/Factin + ATP higher affinity actin so dissociate

c.Profilin and thymosin: Profilin binds to (-) end = plus end grow fast

d.Thymosin buffer + actin monomer = prevent polymerization or ATP hydrolysis.

e.Actin monomer (is above Kd) & regulates actin filament assembly.

Arp2/3 comples to make a seed (nucleate) acting growth. Can create tree-like web

Myosin II structure: motor protein makes force in skeletal contraction muscles.

a.Heavy chain with NT head (ATPase... Continue reading "Cell Biology: Actin, Myosin, and Microtubules" »

Essential Human Body Nutrients and Dietary Needs

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Basic Nutrients

The human body is two-thirds water. Water is an essential nutrient that is involved in every function of the body. Water helps transport nutrients and waste products in and out of cells. Water is necessary for all digestive, absorption, circulatory, and excretory functions. Water is needed for the utilization of the water-soluble vitamins. It is needed for the maintenance of proper body temperature. It is recommended that you drink at least eight 8 glasses of water each day.

Dietary Recommendations

Carbohydrates

  • It is recommended that about 60 percent of your total daily calories come from carbohydrates.
  • If much of your diet consists of healthy complex carbohydrates, you should easily fulfill the recommended daily minimum of 25 grams
... Continue reading "Essential Human Body Nutrients and Dietary Needs" »

Air law

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A Minimal pair is a pair of words that vary by only A single sound, usually meaning sounds that may confuse English learners, like The /f/ and /v/ infanandvan, Or the /e/ and /ɪ/ indeskanddisk

Minimal Pairs /ɪ/ and /i:/sit Seat

Minimal Pairs /e/ and /ɪ/desk disk

Minimal Pairs /e/ and /eɪ/wet wait

Minimal Pairs /æ/ and /ʌ/bat but

Minimal Pairs /əʊ/ and /ɔ:/sosaw

Minimal Pairs /ɒ/ and /əʊ/not note

Minimal Pairs /æ/ and /e/bad bed

Minimal Pairs /ɑ:/ and /ɜ:/fast first

Consonant Sounds

Minimal Pairs /b/ and /v/berryvery

Minimal Pairs /b/ and /p/buypie

Minimal Pairs /n/ and /ŋ/thinthing

Minimal Pairs /l/ and /r/alive arrive

Minimal Pairs /ʧ/ and /t/catchcat

Minimal Pairs /s/ and /ʃ/seashe

Minimal Pairs /f/ and /v/fanvan

Minimal Pairs /f/ and /h/

... Continue reading "Air law" »

Kidney Function, Blood Composition, and Circulatory System Basics

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How Kidneys Work: Filtration and Waste Elimination

Solid waste products need to be dissolved in water to be eliminated from the body.

The Nephron: The Kidney's Functional Unit

Each kidney contains over a million functional units called nephrons, where the filtering process takes place.

Parts of the Nephron

  • Bowman’s Capsule: Surrounds a tiny network of capillaries.
  • The Tubule: Shaped like a handle, several nephrons empty into a large tube called a collecting duct.
  • The Collecting Duct: Moves urine into the renal pelvis.

Kidney Function Process

  1. Blood moves through the capillary networks where filtration occurs. Small molecules such as water, salts, glucose, and urea exit the bloodstream and enter Bowman’s capsule, forming the filtrate.
  2. Some of the molecules
... Continue reading "Kidney Function, Blood Composition, and Circulatory System Basics" »

Animal Tissues, Dental Anatomy, and Digestion

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Four Types of Animal Tissues

1. Epithelial Tissue

  • Squamous:
    • Simple: One cell thick; forms solid layers of cells.
    • Stratified: Multiple layers; forms the epidermis.
  • Cuboidal:
    • Simple: One cell thick, roughly cube-shaped. Lines ducts where absorption and secretory activities take place.
  • Columnar:
    • Simple: One cell thick, column-shaped. Lines the digestive tract.
    • Pseudostratified: Gives the appearance of more than one layer of columnar epithelial organs.

2. Connective Tissue

  • Adipose: Honeycomb or chicken wire appearance. Stores energy, insulates, and supports and protects organs.
  • Dense: Forms ligaments and the outer protective covering for bone.
  • Bone: Tree ring-like appearance. Supports and protects, stores minerals and fat, and aids in blood cell production.
... Continue reading "Animal Tissues, Dental Anatomy, and Digestion" »

Essential Genetics Terminology & Concepts

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Essential Genetics Terminology

Conjugation: Genetic Material Transfer

Conjugation is the transfer of genetic material between unicellular individuals through direct cell-to-cell contact.

Bacterial Conjugation: Not Sexual Reproduction

Bacterial conjugation is often incorrectly regarded as the bacterial equivalent of sexual reproduction or mating.

Spermatogenesis: Male Sperm Development

Spermatogenesis is the process by which male spermatogonia develop into sperm cells.

Oogenesis: Female Egg Development

Oogenesis is the process by which female oogonia develop into egg cells.

Monohybrid Cross: Single Trait Inheritance

A monohybrid cross is a method of tracking the inheritance of a single trait from a pair of homozygous grandparents through generation F1... Continue reading "Essential Genetics Terminology & Concepts" »

Developmental Biology and Genetic Disorders

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Cellular Development Stages

The early stages of development occur at the cellular, tissue, and organ levels of organization. At the cellular level, development includes cleavage, resulting in a multicellular embryo and the formation of a blastula.

Cleavage, which encompasses DNA replication and mitotic stages, is cell division without growth and results in a morula, a ball of cells. The next cellular stage is the formation of a blastula, a hollow ball of cells with a fluid-filled cavity called a blastocoel. The blastocoel forms when the cells of the morula pump Na+ into extracellular spaces, and water follows by osmosis.

Tissue Development Stages

The tissue stages of development are the early gastrula and the neurula. The early gastrula stage begins... Continue reading "Developmental Biology and Genetic Disorders" »

The Respiratory System: Oxygen In, Carbon Dioxide Out

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Enables oxygen in the air to enter the body, expelling carbon dioxide.

1) Respiratory Tract:

Passages through which oxygen enters the lungs and carbon dioxide is expelled.

  • Nasal Passages: Air enters the nose and continues through these passages, where it is moistened and warmed. Dust and microorganisms in the air are retained here.
  • Pharynx: Air from the nasal passages reaches the pharynx, which is part of both systems.
  • Larynx: Made of cartilage. The vocal cords vibrate and enable humans to make sounds.
  • Trachea: C-shaped cartilage rings through which air travels from the larynx to the bronchi.
  • Bronchi and Bronchioles: Bronchi are two tubes that branch out from the trachea into each lung. They divide into small tubes called bronchioles, rounded sacs
... Continue reading "The Respiratory System: Oxygen In, Carbon Dioxide Out" »

Understanding Bone Formation and Craniofacial Growth

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Bone Formation Processes

Intramembranous Bone Formation

Bone forms via the direct secretion of bone matrix within connective tissue, without any intermediate formation of cartilage. There is no formation of cartilage in this process.

Key characteristics:

  • Occurs in the periosteum (external part), endosteum, alveolar bone, and sutures.
  • In the craniofacial vault complex, this type occurs specifically in the cranial vault and jaws.

Endochondral Bone Formation

In this process, cartilage is converted into bone.

Key characteristics:

  • In early stages, cartilage is present from the nose to the cranial base and occipital bone.
  • Prenatally, a series of synchondroses exist within and between the ethmoid, sphenoid, and occipital bones. These facilitate rapid increase
... Continue reading "Understanding Bone Formation and Craniofacial Growth" »

Fundamentals of Microbiology and Bacterial Cell Structure

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Pioneers of Microbiology

  • Louis Pasteur: Father of microbiology.
  • Alexander Fleming: Discovered penicillin.
  • Robert Koch: Proposed the germ theory of disease.
  • Joseph Lister: Introduced the use of antiseptics in surgery.

Prokaryotic vs. Eukaryotic Cells

  • Prokaryotic cell: Small and simple without any membrane-bound organelles; contains peptidoglycan.
  • Eukaryotic cell: Larger and more complex; contains mitochondria but no peptidoglycan.

Bacterial Cell Structures

Bacteria: The most abundant organisms on Earth, usually playing a positive role.

External Structures

  • Glycocalyx (sugar coat): An adhering layer of polysaccharides and proteins that protects against dehydration and serves as a source of food.
  • Biofilms: Microcolonies of bacteria attached to surfaces.
  • Flagella:
... Continue reading "Fundamentals of Microbiology and Bacterial Cell Structure" »