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***Specific Immune response:
-T lympocytes,cellular(T helpers: T h1 and T h2 , T cytotoxic cells)
• B lymphocytes(humoral) → plasma cells→ IgG, IgM, IgA, IgE, IgD
[AMED]
• Antigen presenting cell: Dendrite /macrophages / B Cells
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***Histocomability:
MHC1 :
-all nucleated Cells & platlets
-peptides from protien made inside cell
-CD8+ cytotocix cell recogniztion--------->Class molecules I
MHC II:
-antigen presenting cell
-Class II molecules present exogenous antigens that are first processed in the phagolysosomes.
-CD4+ can recognize peptides presented as a complex with self class II molecules.
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***Humoral immune response ( specific developed)
-Antbodies <------ Plasma cells<--------------B Lymphocyte
- eliminates extracellular microbes & eliminates toxins ( neutralization , opsinization , complement system activation )
-Antibodies : Ig ( AEDGM)
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^^T lymphocyte Activation :
-Binding of peptide MHC complex by T cell receptor
-Co stimulatory signal delivered by same APC
^^Cytotoxic cell Require activation :
1- Activation of dendrites
2- presene of CD4T cells
TH2------>+ B cells to differentiate to plasma cell and produce Ig
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^^Cells of immuen granulosum :
1-Epitheliod cells – derived from macrophages :
2-Giant cells – formed by fusion of macrophages
4-Lymphocytes
5-Other cells : can be also plasma cells, neutrophils, eosinophil
^^Granulosum induces:
1-Mycobacterium tuberculosis
2• Treponema pallidum
3• Mycobacterium leprae
4• Yersinia pseudoturbeculosis
5• Echinococcus
6• Foreign body granulom